Composition and Presentation:

A bottle containing 5 ml. Each ml contains:
PRIVATEPolymyxin B sulphate 6 000 units
Neomycin sulphate 3 500 units
Dexamethasone 1,0 mg

Properties:

Maxicil is a combination antibiotic, Polymyxin B is effective against gram-negative bacteria and is bactericidal such as: Enterobacter, Escherichia, Haemophilus, Klebsiella, Pasteurella, Salmonella, Shigella, Vibrio and Pseudomonas. Neomycin sulphate is a broadspectrum antibiotic. Gram-negative species that are highly sensitive are E. coli, Enterobacter, Aerobacter aerogenes, K. pneumoniae, Pasteurella, Pr. vulgaris, Salmonella, Shigella, H. influenzae, N. meningitidis, V. cholerae and B. pertussis. Gram-positive microorganisms that are inhibited include Bacillus anthracis, C. diphtheriae, Staph. aureus, Strep. faecalis, List. monocytogenes and M. tuberculosis. Borelia and Leptospira interrogans are also suppressed. The sensitivity of Pseud. aeruginosa is variable. Neomycin is active against tubercle bacilli, regardless of their susceptibility to streptomycin. Dexamethasone is steroidal anti- inflammatory agent, it readily penetrates the cornea.

Indications:

In the management of infectious ocular inflammations produced by organisms which are sensitive to the antibiotics neomycin sulphate and polymyxin B sulphate. Acute or chronic non-purulent conjunctivitis, blepharoconjunctivitis and keratoconjunctivitis; non-specific superficial keratitis; deep keratitis; acne rosacae keratitis; iridocyclitis; mild acute iritis, recurrent marginal ulceration; scleritis; episcleritis; scleroconjunctivitis; herpes zoster ophthalmicus (do not use in herpes simplex).

Contraindications:

Maxicil is contra-indicated in tubercular, fungal and most viral lesions of the eye (herpes simplex-dendritic keratitis); vaccinia varicella, acute purulent conjunctivitis and acute purulent blepharitis and in those persons who have shown hypersensitivity to any of its components. Mechanical lacerations and abrasions.

Side Effects:

- Hypersensitivity to anti depressant drugs.
- Ocular hypertension and / or glaucoma.

Warnings:

Corticosteroids may delay wound healing,
Prolonged use may result in glaucoma, damage to the optic nerve, defects in visual acuity and fields of vision, posterior subcapsular cataract formation, or may aid in the establishment of secondary ocular infection.
Prolonged local use of neomycin should be avoided as it may lead to sensitisation. Hypersensitivity reactions, usually of the delayed type have occurred during local treatment with neomycin but may be masked by the dexamethasone.

Dosage:

Instill one to two drops topically in the conjunctival sac(s) four to six times daily. Dosage may be reduced after three to four days when satisfactory improvement has been obtained.